Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Identifieur interne : 000233 ( Main/Exploration ); précédent : 000232; suivant : 000234Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Auteurs : Youngchang Kim [États-Unis] ; Robert Jedrzejczak [États-Unis] ; Natalia I. Maltseva [États-Unis] ; Mateusz Wilamowski [États-Unis] ; Michael Endres [États-Unis] ; Adam Godzik [États-Unis] ; Karolina Michalska [États-Unis] ; Andrzej Joachimiak [États-Unis]Source :
- Protein science : a publication of the Protein Society [ 1469-896X ] ; 2020.
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs, the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses. This article is protected by copyright. All rights reserved.
DOI: 10.1002/pro.3873
PubMed: 32304108
Affiliations:
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There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs, the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses. This article is protected by copyright. All rights reserved.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Kim, Youngchang" sort="Kim, Youngchang" uniqKey="Kim Y" first="Youngchang" last="Kim">Youngchang Kim</name></region><name sortKey="Endres, Michael" sort="Endres, Michael" uniqKey="Endres M" first="Michael" last="Endres">Michael Endres</name><name sortKey="Godzik, Adam" sort="Godzik, Adam" uniqKey="Godzik A" first="Adam" last="Godzik">Adam Godzik</name><name sortKey="Jedrzejczak, Robert" sort="Jedrzejczak, Robert" uniqKey="Jedrzejczak R" first="Robert" last="Jedrzejczak">Robert Jedrzejczak</name><name sortKey="Joachimiak, Andrzej" sort="Joachimiak, Andrzej" uniqKey="Joachimiak A" first="Andrzej" last="Joachimiak">Andrzej Joachimiak</name><name sortKey="Maltseva, Natalia I" sort="Maltseva, Natalia I" uniqKey="Maltseva N" first="Natalia I" last="Maltseva">Natalia I. Maltseva</name><name sortKey="Michalska, Karolina" sort="Michalska, Karolina" uniqKey="Michalska K" first="Karolina" last="Michalska">Karolina Michalska</name><name sortKey="Wilamowski, Mateusz" sort="Wilamowski, Mateusz" uniqKey="Wilamowski M" first="Mateusz" last="Wilamowski">Mateusz Wilamowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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